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目的:对比化疗+手术治疗及化疗+放射治疗年轻高危宫颈癌患者的疗效,探讨更有效的治疗方法。方法:43例年轻高危宫颈癌患者按治疗方法的不同分为两组,(1)化疗+手术组23例,采用以铂类为主的化疗2周+广泛子宫切除及淋巴取样。(2)化疗+放射组20例,采用铂类为主化疗+放疗(全盆外照,Dr26～30Gy;四野外照,Dr24～28Gy+腔内,8～9周完成)。结果:化疗+手术组中位生存期38个月,化疗+放射组中位生存期为35个月,两组生存曲线差异无显著性(P>0.05),但化疗+手术组的生存质量明显高于化疗+放疗组。结论:化疗+手术治疗可作为年轻高危宫颈癌患者的主要治疗方法,可明显提高患者的生存质量。
Objective: To compare the efficacy of chemotherapy + surgery and chemotherapy + radiation in the treatment of young patients with high-risk cervical cancer and explore more effective treatment. Methods: Forty-three cases of young patients with high-risk cervical cancer were divided into two groups according to the different treatment methods. (1) Chemotherapy + operation group (23 cases), platinum-based chemotherapy for 2 weeks + extensive hysterectomy and lymph sampling. (2) Chemotherapy plus radiotherapy group (n = 20) received platinum-based chemotherapy + radiotherapy (whole basin external irradiation, Dr26-30 Gy; Shino external, Dr24-28Gy + cavity, 8-9 weeks). Results: The median survival time was 38 months in chemotherapy plus surgery group and 35 months in chemotherapy + radiation group. There was no significant difference in survival curves between the two groups (P> 0.05), but the quality of life in chemotherapy + surgery group was significantly Higher than chemotherapy + radiotherapy group. Conclusion: Chemotherapy + surgery can be used as the main treatment for young patients with high risk of cervical cancer, which can significantly improve the quality of life of patients.