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目的:观察酪酸梭菌二联活菌散防治婴幼儿肺炎继发腹泻的效果。方法:选取婴幼儿肺炎患儿248例,随机分为预防组138例和对照组110例。在抗感染、扩张支气管、祛痰止咳、预防或纠正水及电解质紊乱、缺氧者予氧疗等常规治疗基础上,预防组同时加用酪酸梭菌二联活菌散口服:≤6个月每次250 mg,>6个月每次500 mg,每天2次,疗程1周,而对照组在有患儿出现腹泻时才开始同法加用酪酸梭菌二联活菌散。观察两组患儿腹泻发生率、临床疗效、止泻时间及腹泻总疗程并进行统计学分析。结果:预防组腹泻发生率为18.1%,对照组腹泻发生率为38.2%,两组比较差异有统计学意义(P<0.01);预防组腹泻治疗总有效率88.0%,高于对照组的66.3%(P<0.05);预防组止泻时间和腹泻总疗程分别为(2.2±0.9)d、(3.6±1.5)d,均短于对照组的(4.3±1.4)d、(6.3±1.6)d(P均<0.01)。结论:酪酸梭菌二联活菌散防治肺炎继发腹泻,疗效确切,可作为防治婴幼儿肺炎继发腹泻的有效方法,值得临床推广应用。
Objective: To observe the effect of Clostridium butyricum inactivated diarrhea in children with pneumonia. Methods: A total of 248 children with infantile pneumonia were selected and randomly divided into prevention group (n = 138) and control group (n = 110). On the basis of anti-infective, bronchial expansion, expectorant and cough prevention, prevention or correction of water and electrolyte disorders and hypoxia-given oxygen therapy, the prevention group was treated with Clostridium butyricum inactivated simultaneously: ≤6months Each 250 mg,> 500 mg for 6 months, 2 times a day, treatment for 1 week, while the control group in the children with diarrhea only began to act together with Clostridium butyricum Clostridium difficile. The incidence of diarrhea, clinical curative effect, antidiarrheal time and total course of diarrhea in both groups were observed and statistically analyzed. Results: The incidence of diarrhea was 18.1% in prevention group and 38.2% in control group, the difference was statistically significant (P <0.01). The total effective rate of diarrhea prevention group was 88.0%, which was higher than that of control group % (P <0.05). The duration of antidiarrheal and diarrhea in the prophylaxis group were (2.2 ± 0.9) days and (3.6 ± 1.5) days respectively, which were shorter than those in the control group (4.3 ± 1.4 days, d (all P <0.01). Conclusion: Clostridium butyricum inactivated diarrhea prevention and treatment of pneumonia, the exact effect, as an effective prevention and treatment of secondary pneumonia in infants and young children diarrhea, worthy of clinical application.