近年来,由于一些新药的广泛应用和对于药物对肝损害的深入研究,药物所致肝脏损害的报告显著增加。这些损害大体可分为急性和慢性两类。前者主要包括肝细胞中毒性和淤胆性两种损害;后者主要包括慢性活动性肝炎、亚急性肝坏死及肝硬化等。其中肝细胞中毒性损害主要表现为急性中毒性肝炎、肝坏死或脂肪变性,这些损害特别是广泛性肝坏死可进展为肝细 In recent years, reports of drug-induced liver damage have increased significantly due to the extensive use of new drugs and in-depth study of drug damage to liver. These injuries can be roughly divided into acute and chronic categories. The former includes hepatotoxicity and cholestatic two kinds of damage; the latter mainly include chronic active hepatitis, subacute hepatic necrosis and cirrhosis. Among them, hepatotoxicity is mainly manifested as acute toxic hepatitis, hepatic necrosis or steatosis. These lesions, especially extensive hepatic necrosis, can progress to liver thin