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琥珀胆碱是目前国内常用的去极化肌松药,此药有许多优点:(1)启效快,时效短,肌松佳,可以静注,肌注或静滴,便于调节肌松程度,并控制其时效,在紧急情况下可以气管内或舌下注药。(2)在常用剂量范围对组织没有毒性,使用安全。(3)对一般病人不产生严重的心血管不良反应。但经临床上多年广泛应用,已发现所存在的缺点也不少,甚至可威胁病人生命。有些不良反应显然与琥珀胆碱的去极化作用直接或间接有关。本综述的重点即在阐明琥珀胆碱并非理想的肌松药,分10项陈述。
Succinylcholine is currently used to depolarizing muscle relaxants, this medicine has many advantages: (1) quick onset, short duration, muscle pine good, intravenous, intramuscular or intravenous infusion, easy to regulate muscle relaxation, And control their aging, in case of emergency can be intratracheal or sublingual injection. (2) Toxicity to tissues at normal dose range, safe to use. (3) does not produce serious adverse cardiovascular reactions to the general patient. However, after many years of clinical application, it has been found that there are many shortcomings that may even threaten the patient’s life. Some adverse reactions are obviously directly or indirectly related to the depolarization of succinylcholine. The focus of this review, which states that succinylcholine is not an ideal muscle relaxant, is divided into 10 statements.