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应用放射免疫分析法(RIA)对120例肝病患者血清的层粘蛋白(Laminin,LN)、透明质酸(Hyaluronic,HA)和Ⅳ型胶原(Type Ⅳ collagen,Ⅳ·C)含量进行测定。结果:肝病组的HA、LN、Ⅳ·C的含量均高于对照组(P<0.001),肝硬化组、肝癌组高于慢性肝炎组(P<0.001),肝硬化组与肝癌组之间无显著性差异(P>0.05)。表明,随着肝纤维化的形成,血清中HA、LN、Ⅳ·C的含量增多,并且与纤维化的程度成正相关。故认为HA、LN、Ⅳ·C是了解肝纤维化程度的良好指标,有利于慢性肝炎的分期,并可以观察抗纤维化治疗的效果。
Serum levels of laminin (LN), hyaluronic acid (HA) and type Ⅳ collagen (Ⅳ · C) were measured by radioimmunoassay (RIA) in 120 patients with liver disease. Results: The content of HA, LN and Ⅳ · C in the liver disease group were higher than those in the control group (P <0.001). The liver cirrhosis group and the liver cancer group were higher than those in the chronic hepatitis group (P <0.001) No significant difference (P> 0.05). It showed that with the formation of hepatic fibrosis, the content of HA, LN and IV · C in serum increased, and it was positively correlated with the degree of fibrosis. So that HA, LN, IV · C is a good indicator of the degree of understanding of liver fibrosis, is conducive to chronic hepatitis staging, and can observe the effect of anti-fibrosis treatment.