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[背景]双酚A(BPA)是一种广泛使用的内分泌干扰化学物,与啮齿类动物体重增加和脂肪沉积有关联。[目的]在CHAMACOS纵向队列的9岁儿童组(n=311)中,研究产前和产后尿BPA浓度与体质指数(BMI)、腰围、体脂肪率和肥胖间的关联。[方法]采集母亲怀孕期间现场收集的两次尿样以及5岁和9岁儿童的尿样,测量BPA浓度。[结果]产前尿BPA浓度与9岁女孩BMI降低有关联,但在男孩中无此关联。在女孩中,位于产前BPA浓度最高的三分位数与BMI z分值降低(β=-0.47,95%CI:-0.87～-0.07)和体脂肪率降低(β=-4.36,95%CI:-8.37～-0.34)有关联;与位于最低三分位数组的女孩相比,超重/肥胖的风险下降[比值比(OR)=0.37,95%CI:0.16～0.91]。这些发现在青春期前期的女孩中最强。5岁时的尿BPA浓度与5岁或9岁时任何人体测量学参数没有相关性,在9岁时的BPA浓度与男孩和女孩9岁时的BMI、腰围、脂肪量、超重/肥胖呈正相关。[结论]本研究的发现与其他横断面研究相一致,9岁时尿BPA浓度较高与9岁时肥胖增加相关联。然而,母亲怀孕期间BPA浓度增加与他们的女儿9岁时BMI、体内脂肪和超重/肥胖降低有关联。
[Background] Bisphenol A (BPA) is a widely used endocrine-disrupting chemical that is associated with weight gain and fat deposition in rodents. [Objectives] To investigate the association between pre-natal and postpartum urinary BPA concentrations and body mass index (BMI), waist circumference, body fat percentage and obesity in a 9-year-old CHAMACOS cohort cohort (n = 311). [Methods] The urinary samples collected from the mother during field pregnancy and the children aged 5 and 9 years were collected to measure the BPA concentration. [Results] Prenatal urinary BPA levels were associated with decreased BMI in 9-year-old girls, but not in boys. Among girls, the highest tertile of prenatal BPA was associated with a lower BMI z score (β = -0.47, 95% CI: -0.87 to -0.07) and a lower body fat percentage (β = -4.36, 95% CI: -8.37 to -0.34); the risk of overweight / obesity decreased compared with girls in the lowest tertile group (odds ratio = 0.37, 95% CI: 0.16-0.91). These findings are strongest among adolescent girls. Urinary BPA concentrations at 5 years of age were not associated with any of the anthropometric parameters at 5 years or 9 years of age and BPA concentrations at 9 years were positively correlated with BMI, waist circumference, fat mass, overweight / obesity at 9 years of age for boys and girls . [Conclusions] The findings of this study are consistent with other cross-sectional studies. Higher urinary BPA levels at age 9 are associated with increased obesity at age 9 years. However, increased maternal BPA concentrations during pregnancy were associated with a decrease in BMI, body fat and overweight / obesity at 9 years of age in their daughters.