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肝细胞生长因子 (HGF)是由间质细胞产生 ,作用于上皮细胞 ,具有多种生物活性的细胞因子。其受体是c met原癌基因产物。HGF通过与受体结合引起受体酪氨酸磷酸化 ,转导HGF的效应。HGF可促进细胞分裂、运动和分化等 ,在血管生成、组织损伤修复及促进肿瘤细胞的发生及转移等方面起重要作用。近年的研究证实HGF及其受体在角膜、晶体及视网膜组织中均表达 ,它通过旁分泌和 /或自分泌途径调节角膜、晶体上皮细胞和色素上皮细胞的功能 ,维持组织结构的完整性。但在某些病理条件下 ,对增生性视网膜病变的发生、发展起着重要作用。HGF作为血管生成因子参与了增生性糖尿病性视网膜病变 (PDR)视网膜新生血管的生成 ,使PDR患者玻璃体hHGF的浓度明显高于正常人 ,并与视网膜新生血管出现的严重程度呈正相关。另一方面 ,HGF对色素上皮细胞具有增殖和趋化作用 ,使色素上皮细胞在玻璃体内及视网膜表面形成增殖膜 ,是参与增生性玻璃体视网膜病变形成和发展的又一生长因子
Hepatocyte growth factor (HGF) is produced by interstitial cells, acting on epithelial cells, with a variety of biological activity of cytokines. Its receptor is the c met proto-oncogene product. HGF transduces HGF by causing receptor tyrosine phosphorylation by binding to the receptor. HGF can promote cell division, motility and differentiation, and play an important role in angiogenesis, tissue damage repair and promotion of tumor cell generation and metastasis. Recent studies have confirmed that HGF and its receptors are expressed in cornea, lens and retina. It regulates the function of cornea, lens epithelial cells and pigment epithelial cells through paracrine and / or autocrine pathways to maintain the integrity of tissue structure. However, in some pathological conditions, the occurrence and development of proliferative retinopathy play an important role. HGF, as an angiogenic factor, is involved in the formation of retinal neovascularization in proliferative diabetic retinopathy (PDR). The concentration of hHGF in vitreous body in PDR patients is significantly higher than that in normal people, and is positively correlated with the severity of retinal neovascularization. On the other hand, HGF has a proliferative and chemotactic effect on the pigment epithelial cells, which makes the pigment epithelial cells form proliferative membranes in the vitreous body and on the retina surface, which is another growth factor involved in the formation and development of proliferative vitreoretinopathy