脂质用作烧伤后的营养支持一直是有争议的。反对者认为高水平的脂质对免疫反应有不利作用和病人易受感染。以往的研究提示膳食中亚油酸含量太多而致花生四烯酸(AA)代谢途径过度激活对烧伤病人是有害的。本文考察以鱼油方式提供花生五烯酸(EPA)是否可预防烧伤后免疫反应抑制以及亚油酸的其他不利作用。 66只雌性豚鼠,体重419±3g,经手术放置胃饲管,管端自背部高位肩胛骨间导出。术后7～10天制造 Lipid use as a nutritional support after burn has always been controversial. Opponents argue that high levels of lipids have an adverse effect on the immune response and that the patient is susceptible to infection. Previous studies have suggested that too much linoleic acid in the diet and excessive activation of arachidonic acid (AA) metabolic pathways are detrimental to burn patients. This article examines whether providing arachidonic acid (EPA) as a fish oil can prevent the suppression of post-burn immune response and other adverse effects of linoleic acid. 66 female guinea pigs weighing 419 ± 3g were surgically placed in the stomach feeding tube and the tube end was led out from the high back scapula. 7 to 10 days after the manufacture