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目的 讨论小儿神经母细胞瘤 (NB)诊断、治疗与预后特点。方法 分析 1987～ 1999年间收治小儿NB97例 ,以尿中 3-甲氧基 - 4-羟基杏仁酸 (VMA)、B超、磁共振、骨穿及病理检查确诊。术前确诊患儿化疗 12～ 18天。全部病例肿瘤切除。结果 97例NB术后 15个月内先后复发来院再次治疗 5 0例 ,仅 2例再次手术切除肿瘤 ,病理检查已趋向神经节细胞瘤。结论 NB已经确定诊断者首次化疗效果明显 ,其后是手术的良好时机。骨穿和尿VMA检查是诊断NB的较好方法
Objective To discuss the diagnosis, treatment and prognosis of pediatric neuroblastoma (NB). Methods Analysis of pediatric NB97 cases from 1987 to 1999 was confirmed by urinary 3-methoxy-4-hydroxymalonic acid (VMA), B-ultrasonography, magnetic resonance imaging, bone puncture, and pathological examination. Preoperative diagnosis of children with chemotherapy 12 to 18 days. All cases tumor resection. Results 97 cases of NB relapsed within 15 months after operation and 50 cases were treated again. Only 2 cases were re-surgically resected. The pathological examination has been towards ganglion cell tumors. Conclusions NB has established that the first chemotherapy of the diagnosis is effective, followed by a good opportunity for surgery. Bone puncture and urine VMA examination is a better way to diagnose NB