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目的 探讨白三烯受体拮抗剂辅助治疗成人过敏性紫癜性肾炎的临床疗效.方法 将90例过敏性紫癜性肾炎成人患者采用随机数字表法分为两组,各45例.两组均给予泼尼松治疗,研究组联合白三烯受体拮抗剂治疗,观察1个月.比较治疗前后两组肾功能指标、血生化指标和水肿、高血压改善情况.结果 治疗后两组血肌酐、尿素氮、尿蛋白、免疫球蛋白A、免疫球蛋白G、白介素-6、白三烯B4水平均显著低于治疗前(P＜0.01),研究组较对照组下降更显著(P＜0.05或0.01).治疗后两组水肿及高血压患者显著少于治疗前(P＜0.01),研究组较对照组减少更显著(P＜0.05).结论 白三烯受体拮抗剂治疗过敏性紫癜性肾炎的成人患者临床疗效及安全性均较好,值得推广应用.“,”Objective To investigate the clinical effect of LTRA adjuvant therapy in adult anaphylatic purpura nephritis. Methods 90 cases with anaphylatic purpura nephritis were randomly divided into two groups, 45 cases in each group. The two groups were all given prednison treatments, the observation group was given LTRA adjuvant therapy on this basis, patients were observed for 1 month. Compare the renal function indexes, blood biochemical indexes, edema and hypertension improvement condition of the two groups before and after treatment. Results After treatment, Scr, BUN, PRO, IgA, IgG, IL-6, LTB4 of the two groups were all significantly lower than those before treatment (P＜0.01), the observation group declined more significantly than the control group(P＜0.05 or 0.01). After treatment, patients with edema and hypertension were significantly less than those before treatment (P＜0.01),the observation group declined more significantly than the control group(P＜0.05). Conclusion LTRA adjuvant therapy in adult anaphylatic purpura nephritis has better clinical effect and safety, it is worthy of popularization and application.