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干扰素(IFN)具有预防病毒感染的作用,在各种IFN中,以IFN-γ的免疫调节作用最强。本文研究慢性肝炎(CH)病人中,周围血单核细胞(PBMC)在体外产生IFN-γ的活性,该药物的治疗效果以及IFN-γ产生能力和HBV复制的关系。对象与方法:IFN-γ是由人PBMC与经青霉素处理的链球菌(化脓性Su株)-(OK_(432))一起培养后产生。正常对照组(NC)29例,CH44例,肝硬化(CL)24例,肝细胞性肝癌(HCC)21例。14例CH经OK_(432),IFN-β或阿糖胞苷腺嘌吟(Ara-A)治疗。具体给药方
Interferon (IFN) has the effect of preventing viral infection, and the immunomodulatory effect of IFN-γ is strongest in all kinds of IFN. The aim of this study was to investigate the in vitro production of IFN-γ by peripheral blood mononuclear cells (PBMCs) in patients with chronic hepatitis (CH), the therapeutic effect of this drug and the relationship between the production of IFN-γ and HBV replication. Subjects and Methods: IFN-γ was generated after human PBMCs were cultured with penicillin-treated Streptococcus (suppurative Su strain) - (OK_ (432)). The control group (NC) consisted of 29 patients, 44 patients with CH, 24 with cirrhosis (CL) and 21 with hepatocellular carcinoma (HCC). Fourteen CHs were treated with OK_ (432), IFN-β, or Ara-A. Specific administration side