论文部分内容阅读
目的:探索四种血清肿瘤标记物对肝病的诊断及临床意义。方法:应用放射免疫法检测甲胎蛋白(AFP)、速率法检测岩藻糖苷酶(AFU)、血清β2微球蛋白(β2-MG)。测定原发性肝癌50例、肝硬化患者50例、其他恶性肿瘤患者50例、健康体检患者60例血清。结果:原发性肝癌各项指标与其他恶性瘤组、肝硬化组比较除β2-MG无差异(P>0.05)外,其他三项都有显著差别。分别(P<0.01)或有差异(P<0.05)。原发性肝癌组单项AFP、AFU、β2-MG、γ-GT。阳性检出率分别是66%、78%、80%、82%。AFP、AFU、γ-GT,诊断符合率分别是81%、84%、79%。联合检测敏感性达98%,比单项AFP(66%)检测敏感性比较差异有显著意义(P<0.01)结论:联合测定AFP、AFU、γ-GT,可提高对肝癌阳性诊断率,并可提高对肝病鉴别诊断价值。
Objective: To explore the diagnostic value of four serum tumor markers in the diagnosis of liver disease and its clinical significance. Methods: AFP was detected by radioimmunoassay. Fucosidase (AFU) and β2 microglobulin (β2-MG) were detected by the rate assay. 50 cases of primary liver cancer, 50 cases of liver cirrhosis, 50 cases of other malignant tumors, and 60 cases of healthy patients were measured. Results: The indexes of primary liver cancer were significantly different from those of other malignant tumors and cirrhosis except β2-MG (P> 0.05). (P <0.01) or difference (P <0.05). Primary liver cancer group AFP, AFU, β2-MG, γ-GT. Positive detection rates were 66%, 78%, 80%, 82%. AFP, AFU, γ-GT, diagnostic coincidence rates were 81%, 84%, 79%. The sensitivity of combined detection was 98%, which was significantly higher than that of single AFP (66%) (P <0.01). Conclusion: The combined detection of AFP, AFU and γ-GT can improve the positive rate of liver cancer, Improve the differential diagnosis of liver disease.