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目的探讨血浆同型半胱氨酸水平与颈动脉内膜中层厚度的关系。方法取空腹静脉血利用高效液相层析法测定血浆同型半胱氮酸的浓度。利用高分辨率超声仪测定双侧颈动脉内膜中层厚度,动脉粥样硬化的定义为内膜中层厚度(IMT)≥1.3mm,根据超声结果分为颈动脉粥样硬化组(IMT≥1.3mm)和对照组(IMT<1.3mm)。结果颈动脉粥样硬化组高血浆同型半胱氨酸水平明显高于对照组,差异有显著性(P<0.05)。颈动脉粥样硬化组高同型半胱氨酸血症的检出率高于对照组(49.1%/9.8%X2=14.6P<0.01)。Logistic回归分析显示血浆同型半胱氨酸水平与颈动脉粥样硬化发生相关(OR=2.811,P=0.023,95%CI1.131~4.724),独立于年龄和空腹血糖水平。结论颈动脉粥样硬化患者血浆同型半胱氨酸水平明显升高,高同型半胱氨酸血症的检出率高。血浆同型半胱氨酸是颈动脉硬化的独立危险因素。
Objective To investigate the relationship between plasma homocysteine level and intima-media thickness of carotid artery. Methods Fasting venous blood plasma concentrations of homocysteine were determined by high performance liquid chromatography. High-resolution ultrasound was used to measure bilateral carotid intima-media thickness, and atherosclerosis was defined as intima-media thickness (IMT) ≥1.3 mm. According to the results of ultrasound, the carotid atherosclerosis group (IMT≥1.3 mm ) And control group (IMT <1.3mm). Results The level of plasma homocysteine in carotid atherosclerosis group was significantly higher than that in control group (P <0.05). The detection rate of hyperhomocysteinemia in carotid atherosclerosis group was higher than that in control group (49.1% / 9.8% X2 = 14.6 P <0.01). Logistic regression analysis showed that plasma homocysteine level correlated with carotid atherosclerosis (OR = 2.811, P = 0.023, 95% CI, 1.31-4.724), independent of age and fasting blood glucose levels. Conclusion Patients with carotid atherosclerosis plasma homocysteine levels were significantly elevated, high homocysteinemia high detection rate. Plasma homocysteine is an independent risk factor for carotid atherosclerosis.