胆囊切除术后次级胆汁酸水平的升高以及胆结石病被认为是增高大肠癌患病风险的因素,而且有研究表明,这二者可能是导致大肠癌的最大的风险因素。虽有许多与此相关的研究结果陆续发表,但这些研究之间仍存在很多矛盾,且目前还不清楚这种风险在直肠是否明显。因此,Chiong等人通过meta分析来探讨患者胆囊切除术后或胆结石情况下患直肠癌的风险。他们前期在PubMed等数据库进行了文献检索,选择了关于成人胆结石病及胆囊切除术与直肠癌之间关系的研究文献,之后 Increased secondary bile acid levels after cholecystectomy and gallstone disease are considered to be factors that increase the risk of colorectal cancer, and studies have shown that both may be the largest risk factors for colorectal cancer. Although many related research results have been published, there are still many contradictions between these studies, and it is not clear whether this risk is obvious in the rectum. Therefore, Chiong and others through meta-analysis to explore the risk of patients with rectal cancer after cholecystectomy or gallstones. They conducted a literature search in databases such as PubMed earlier, selected the research literature on the relationship between adult gallstone disease and cholecystectomy and rectal cancer, and then