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目的探讨血清TPS和VEGF联合检测对乳腺癌诊断的意义。方法用ELISA方法检测50例乳腺癌及25例良性乳腺疾病患者(对照组)血清TPS和VEGF水平。结果乳腺癌组血清TPS,VEGF,T/V水平明显高于对照组(P<0.01);手术后乳腺癌血清TPS,VEGF,T/V水平明显低于手术前,差异有统计学意义(P<0.01);TPS,VEGF,T/V诊断乳腺癌敏感性分别为72%,44%,94%(P<0.01);对TNM分期0～I期乳腺癌诊断敏感性分别为26.67%,6.67%,86.67%(P<0.01)。结论联合检测乳腺癌血清TPS,VEGF水平,并用T/V作为指标对乳腺癌的诊断可能具有重要的临床意义。
Objective To investigate the significance of serum TPS and VEGF in the diagnosis of breast cancer. Methods The levels of serum TPS and VEGF in 50 cases of breast cancer and 25 cases of benign breast disease (control group) were detected by ELISA. Results The levels of serum TPS, VEGF, T / V in breast cancer group were significantly higher than those in control group (P <0.01). The serum levels of TPS, VEGF and T / V in breast cancer were significantly lower than those before operation <0.01). The sensitivity of TPS, VEGF and T / V in diagnosing breast cancer were 72%, 44% and 94%, respectively (P <0.01). The diagnostic sensitivity to TNM staging 0 to I breast cancer were 26.67% and 6.67 %, 86.67% (P <0.01). Conclusion Combined detection of serum TPS and VEGF levels in breast cancer and the use of T / V as an indicator may have important clinical significance in the diagnosis of breast cancer.