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为了拟订合理的化疗方案,提高农村肺结核病防治效果,我们对农村不住院病人痰标本分离的186株结核杆菌耐药情况作了分析,现将结果简要报告如下。实验方法和耐药界限均按“全国结核病细菌学检验方法标准化讨论会”的规定进行。含药培养基包括SM、KM、1 NH、RFP、PAS和EMB六种。结果 1.186株痰结核菌对以上六种药物全敏感者43株(23.1％),耐一至六药143株,耐药率为76.9％。耐一药率为27.4％,耐二药率为22.6％;耐三药率为21.O％;耐四药率为5.4％;耐五药率为0.5％。2.186株耐药病例,初治33例,复治153例。二者对6种药物耐药有显著差异(P<0.001)。(表1)。3.原发耐药率与继发耐药率的比较:两者有非常显著性差异(P<0.001),(表2)。4.耐药发生率与用药的关系:在153例继发耐药病例中,规则用药者41例,耐药26例(63.4％),
In order to formulate a reasonable chemotherapy regimen and improve the effectiveness of prevention and treatment of tuberculosis in rural areas, we analyzed the drug resistance of 186 strains of Mycobacterium tuberculosis isolated from the sputum specimens from rural patients who are not in the hospital, and the results are briefly reported as follows. Experimental methods and resistance limits are based on the “national standardization seminar tuberculosis bacteriology test” requirements. Drug-containing media include SM, KM, 1 NH, RFP, PAS and EMB six. Results 1.186 strains of sputum TB were 43 (23.1%) sensitive to the above six drugs, resistant to one to six drugs 143 strains, the resistance rate was 76.9%. Resistance-resistant rate was 27.4%, resistant to two drug rates was 22.6%; resistance to three drug rates was 21. O%; resistance to four drug rates was 5.4%; resistant to five drug rates of 0.5%. 2.186 resistant cases, initial treatment in 33 cases, 153 cases of retreatment. There was a significant difference in resistance to the six drugs (P <0.001). (Table 1). 3. The primary resistance rate and secondary drug resistance comparison: the two have a very significant difference (P <0.001), (Table 2). 4. The relationship between the incidence of drug resistance and drug use: Among 153 cases of secondary drug resistance, 41 cases were drug-resistant, with drug resistance in 26 cases (63.4%),