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本文报告了大鼠甲基汞中毒的早期神经症状——尾转动的毒理学实验。95只Wistar系大鼠,食用含有20 ppm的甲基汞和0.1 ppm硒的饲料,食物和饮水量任意摄取。每周称体重二次,每天对死亡数和神经症状(步态失调、平衡、矫正反射、对触击的反应、尾转动、后肢交叉……)进行观察。实验开始后5～6周,即在体重减轻和后肢交叉出现前2～3周全部大鼠表现出尾转动的体征。典型尾转动的频率是4～6圈/秒。尾转动的方向:将鼠的躯干沿躯干长轴顺时针方
This article reports the early neurological symptoms of methylmercury poisoning in rats - tail rotation toxicology experiments. Ninety five Wistar rats were eaten with feed containing 20 ppm of methylmercury and 0.1 ppm of selenium, with uptake of food and water. Body weight was weighed weekly twice a day, and the number of deaths and neurological symptoms (gait disorders, balance, corrective reflexes, responses to striking, tail rotation, hindlimb crossover ...) were observed daily. Five to six weeks after the start of the experiment, all rats exhibited signs of caudal rotation 2 to 3 weeks prior to the weight loss and hindlimb cross-appearance. Typical tail rotation frequency is 4 ~ 6 laps / sec. Tail rotation direction: the trunk of the mouse clockwise along the long axis