病例 患儿,男,1996年10月2日出生,足月顺产,出生时体重2.1公斤,无毛发,面部皮肤有针头大小丘疹,中央有细刺状物,无其它异常。此后,患儿头部一直未见毛发生出,眉毛和睫毛也非常稀少。头皮、耳后、颈背部以及臀部相继出现针头大小的丘疹。中央有小刺状物,皮肤粗糙。近期肛周出现红斑、渗出,结痂。患儿指甲逐个变形、增厚、与甲体分离,脱落。在当地医院以“湿疹”治疗未见好转,1999年3月18日来我院就诊。发病以来,饮食尚可。父母非 Case of children, male, born on October 2, 1996, full-term birth, weight 2.1 kg at birth, no hair, face size needle-size papules, the central fine thorn, no other abnormalities. Since then, hair has been seen in children’s head, eyebrows and eyelashes are also very rare. Scalp, ear, back of the neck and buttocks have appeared needle-sized papules. Central has a small thorn, rough skin. Recent perianal erythema, exudation, crusting. Pediatric nail deformation one by one, thickening, and the separation of the body, off. In the local hospital with “eczema” treatment did not improve, March 18, 1999 to our hospital. Since the onset, the diet is acceptable. Non-parents