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血管生成素与它的第二种受体(Tie-2)组成的信号系统——ANG-Tie2——控制着血管成熟和休眠,它是一种特异作用于血管的受体酪氨酸激酶系统。ANG-2因为显著上调多数肿瘤中的血管形成而被认为可以在癌症的治疗上发挥重要作用。ANG-2被认为是在肿瘤组织中主要发挥作用的ANG型。研究发现ANG-2抑制剂能发挥一定的抗肿瘤作用,而ANG-2抑制剂与细胞毒药物,VEGF抗体药物或酪氨酸激酶抑制剂的联合应用相比于单一疗法表现出更加显著的抗肿瘤作用。文章就血管生成素信号系统和相关抗肿瘤药物的研发进行了综述。
Angiopoietin and its second receptor (Tie-2) signaling system --ANG-Tie2 - control the blood vessels mature and dormancy, it is a specific role in the vascular receptor tyrosine kinase system . ANG-2 is thought to play an important role in the treatment of cancer because it significantly up-regulates angiogenesis in most tumors. ANG-2 is considered as the ANG type that plays a major role in tumor tissue. The study found that ANG-2 inhibitors can exert a certain anti-tumor effect, while the combination of ANG-2 inhibitors and cytotoxic drugs, VEGF antibody drugs or tyrosine kinase inhibitors showed more significant anti-monotherapy Tumor action. This article reviews the development of angiogenin signaling systems and related antitumor drugs.