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研究蒿甲醚（Ａｒｔ）对血吸虫摄入葡萄糖和糖原含量的影响．方法：用Ａｒｔ３００ｍｇ·ｋｇ－１ｉｇ治疗感染小鼠后２４－４８ｈ取虫，作体外培养，测定♀、♂虫糖原含量，对［Ｕ１４Ｃ］葡萄糖的摄入及［Ｕ１４Ｃ］葡萄糖掺入虫糖原的量．结果：感染小鼠用Ａｒｔ治疗后２４－４８ｈ取虫作体外培养１－２４ｈ，♂和♀虫的糖原含量分别减少２７％－６１％和３９％－７８％；６组♂虫中，仅３组的葡萄糖摄入减少２３％－３５％，而♀虫各组的均明显减少，减少率为１８％－３８％．除２组♂虫外，［Ｕ１４Ｃ］葡萄糖掺入虫的糖原量无明显变化．结论：Ａｒｔ引起血吸虫糖原的减少，可能与干扰糖酵解而不是与葡萄糖的摄入有关．
The effect of artemether on the intake of glucose and glycogen in schistosomiasis was studied. Methods: Infected mice were treated with Art300mg · kg-1ig 24-48h after inoculation, for in vitro culture, determination of ♀, ♂ insect glycogen content, [U 14C] glucose intake and [U 14C] Into the amount of insect glycogen. Results: Infected mice were treated with Art for 24 to 48 hours and cultured for 1-24 hours in vitro. The glycogen content in the male and female worms decreased by 27% -61% and 39% -78%, respectively. Glucose intake decreased by 23% -35% in group 3, while the incidence of pinworm in each group was significantly reduced by 18% -38%. In addition to 2 groups of ♂ worms, [U 14C] glucose incorporation of worms no significant changes in the amount of glycogen. Conclusion: Art caused a decrease of schistosome glycogen, which may be related to interfering with glycolysis rather than glucose intake.