结核病很难治愈,需要至少6个月的使用多种抗生素的治疗。少数菌体能够耐受抗生素,在感染对象肺部长期存在,但细菌生存仍然需要一些代谢活动。我们在豚鼠(其可利用缺氧,并且发生的坏死性肉芽肿在组织学上与人类的相似)体内研究缺氧诱导的Rv1894c基因对结核杆菌毒力的作用,并发现该基因对整个杆菌的生长和生存都是必要的。其特征在于该基因所编码的酶的功能是一种氮酸酯 Tuberculosis is difficult to cure and requires at least 6 months of treatment with multiple antibiotics. A small number of bacteria can tolerate antibiotics, long-term presence in the lungs of infected subjects, but the bacteria still need some metabolic activity. We investigated the effect of the hypoxia-induced Rvl894c gene on the virulence of Mycobacterium tuberculosis in guinea pigs, which can be histologically amalgamated with hypoxia and necrotic granulomas that develop, and found that the effect of this gene on whole Bacillus Growth and survival are all necessary. Characterized in that the function of the enzyme encoded by this gene is a nitrite