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目的探讨非甾体类抗炎药物(NSAIDs)诱发消化性溃疡出血的临床流行病学特点。方法回顾分析1991～2002年诊治的消化性溃疡出血的临床资料,并用电脑数据库处理分析。结果在982例消化性溃疡并出血患者中,27.90%近期内有服用NSAIDs史。服用NSAIDs组与未服用NSAIDs组比较,服用NSAIDs组平均年龄较大[(43.36±14.55)岁比(37.25±13.57)岁,P<0.05];女性相对较多(25.18%比16.67%,P<0.01);胃溃疡比例较高(27.37%比14.27%,P<0.01);外科手术率无明显差别(P>0.05)。结论NSAIDs是诱发消化性溃疡出血的一常见原因,应加强对NSAIDs胃肠毒副作用的防治。
Objective To investigate the clinical epidemiological characteristics of non-steroidal anti-inflammatory drugs (NSAIDs) -induced peptic ulcer bleeding. Methods The clinical data of peptic ulcer bleeding diagnosed and treated from 1991 to 2002 were retrospectively analyzed and analyzed by computer database. Results Of the 982 patients with peptic ulcer bleeding, 27.90% had history of taking NSAIDs in the near future. Compared with those without NSAIDs, the average age of patients taking NSAIDs was significantly higher than that of NSAIDs patients (43.36 ± 14.55 years vs 37.25 ± 13.57 years, P <0.05), and more women (25.18% vs. 16.67%, P < 0.01). The proportion of gastric ulcer was higher (27.37% vs 14.27%, P <0.01). There was no significant difference in the rate of surgical operation (P> 0.05). Conclusion NSAIDs is a common cause of peptic ulcer bleeding, and the prevention and treatment of gastrointestinal side effects of NSAIDs should be strengthened.