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稽留流产是妇产科一种常见病,导致稽留流产的病因包括遗传和环境等因素,但确切机制尚不明确。众多研究表明,稽留流产病因复杂,与p53、MDM2或HDM2及ER等相关基因多态性及Fas/FasL系统、Fas相关死亡结构域蛋白、Livin、survivin、bax、caspase、HIF及AAH等基因表达异常有关;另外环境因素包括化学物质、物理因素(如放射线、噪音及高温等)以及不良生活习惯(如吸烟、饮酒、吸毒、过多使用电脑、手机、生活不规律及职业紧张等)均可引起稽留流产。因此从遗传和环境两方面来进一步研究其发生发展机理,可以更好地给临床实践提供指导。
Retention abortion is a common disease in obstetrics and gynecology, resulting in missed etiology, including genetic and environmental factors, but the exact mechanism is not yet clear. Numerous studies have shown that the cause of missed abortion is complex and the gene polymorphisms related to p53, MDM2 or HDM2 and ER, as well as Fas / FasL system, Fas-related death domain protein, Livin, survivin, bax, caspase, HIF and AAH In addition, environmental factors include chemical substances, physical factors (such as radiation, noise and heat), and unhealthy habits (such as smoking, drinking, drug abuse, excessive use of computers, cell phones, irregular life and occupational stress) Caused missed abortion. So from the genetic and environmental aspects to further study its occurrence and development mechanism, can better provide guidance for clinical practice.