对11例原发性高血压(EH)患者顿服依那普利20mg后,动态观察血清依那普利拉浓度与血压、血浆血管紧张素Ⅱ(AⅡ)、内皮素(ET)心钠素(ANF)水平变化的关系,结果示服药后血药浓度3h达峰值,4h开始下降,7h降至最低;血压效应在1h开始起效,3h最明显,4～7h维持在有效水平;2、4、6h血浆AⅡ、ET和ANF水平逐渐下降,与治疗前比较有显著差异,血药浓度与血压效应的变化一致,血药浓度与血浆AⅡ水平之间呈非线性关系。 Eleven patients with essential hypertension (EH) were treated with enalapril 20 mg daily, and the effects of enalapril concentration and blood pressure, plasma angiotensin Ⅱ (AⅡ), endothelin (atrial natriuretic peptide) (ANF). The results showed that the peak plasma concentration reached the peak at 3h, decreased at 4h, and decreased to the minimum at 7h. The onset of blood pressure began at 1h, the most obvious at 3h, and remained at the effective level at 4 ~ 7h. 4h, 6h plasma AII, ET and ANF levels decreased, compared with before treatment were significantly different, blood concentration and blood pressure changes in the same effect, plasma concentration and plasma A Ⅱ level was a nonlinear relationship.