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本文采用琼脂凝胶电泳方法测定了12例急性心肌梗塞(AMI)血清肌酸激酶 MM 同功酶亚带(CK-MM 亚带)及其 MM_3/MM_1比值的动态变化。结果表明,在 AMI 早期血清 MM_3/MM_1比值最先升高,并于9h 达峰值,然后逐渐下降,并一度低于基础水平,故测定血清 MM_3/MM_1比值诊断梗塞扩展,不如测定 MM_3绝对活力和 CK-MB 敏感。因此在 AMI 早期诊断中,同时测定MM_3和 CK-MB 可弥补 MM_3/MM_1比值的不足。
In this paper, the dynamic changes of serum creatine kinase MM isozyme subband (CK-MM subband) and MM_3 / MM_1 ratio in 12 cases of acute myocardial infarction (AMI) were determined by agarose gel electrophoresis. The results showed that in the early stage of AMI, the ratio of MM_3 / MM_1 increased first and peaked at 9h, then decreased gradually and was lower than the baseline level at the same time. Therefore, the determination of serum MM_3 / MM_1 ratio in the diagnosis of infarct expansion was not as good as the determination of MM_3 absolute activity and CK-MB sensitive. Therefore, in the early diagnosis of AMI, simultaneous determination of MM_3 and CK-MB can make up for the lack of MM_3 / MM_1 ratio.