目的探讨血清CEA与CA199对胰腺癌的诊断价值。方法将患者分为观察组与对照组,分别对两组血清CEA与CA199的检测水平进行比较,并对2者血清CEA与CA199单独和联合检测的阳性检出率,以及观察组单独和联合检测的敏感性和特异性比较分析。结果观察组患者血清CEA与CA199的检测水平比对照组均要高;2组血清CEA与CA199联合检测比单独检测的阳性检出率均更高;观察组血清CEA与CA199联合检测比单独检测的敏感性和特异性均更高,差异均有统计学意义(P<0.05)。结论血清CEA和CA199在临床诊断胰腺癌中均具有参照价值,但不能单独作为参照依据;2者联合检测参照价值明显,值得临床应用。 Objective To investigate the diagnostic value of serum CEA and CA199 in pancreatic cancer. Methods The patients were divided into observation group and control group. The levels of serum CEA and CA199 in the two groups were compared respectively. The detection rates of CEA and CA199 alone and in combination with the two groups were detected separately and jointly The sensitivity and specificity of comparative analysis. Results The serum levels of CEA and CA199 in the observation group were higher than those in the control group. The positive rates of CEA and CA199 in the two groups were higher than those in the control group. The combined detection of serum CEA and CA199 in the observation group was higher than that in the control group Sensitivity and specificity were higher, the differences were statistically significant (P <0.05). Conclusions Serum CEA and CA199 are both valuable in the clinical diagnosis of pancreatic cancer, but they can not be used as a reference alone; 2, the combined detection of reference value is obvious and worthy of clinical application.