[例1]男,33岁,于1967年起经外院多次摄片确诊为石骨症,在骨盆片上除有典型的石骨症表现外,还可见到两侧髂总动脉和股动脉有明显的钙化现象(图1,见插页2)。自1971年开始患者两下肢活动受限,继而肢体肌肉萎缩.次年冬,右足(?)趾出现一黑斑,感微痛,此后黑斑逐渐扩大,疼痛也加剧。至1973年春,黑斑已蔓及三个足趾,夜间痛剧难受,经多种治疗无效后于同年7月作左下肢截除术。病理诊断为:1.左下肢大理石骨;2.左股动脉粥样硬化,中层钙化和骨化;3.左足趾及前1/3足背千性坏疸。1974年初,右足趾又发黑,并伴剧烈疼痛,也因治疗无效而于同年3月作右下肢截除术.[例2]男,22岁,例1胞弟,近6年来因两下肢 [Example 1] Male, 33 years old, was diagnosed as osteosarcoma by multiple radiographs of the outside hospital since 1967. In addition to the typical osteolithiasis in the pelvic radiographs, both common iliac and femoral arteries can be seen Obvious calcification (Figure 1, see insert 2). Since 1971, the patient’s lower extremity activity was limited and his limbs were atrophied. In the following winter, a dark spot and a slight sensation of pain appeared in the right foot (?) Toe, and then the dark spot gradually expanded and the pain intensified. To the spring of 1973, black spots have spread three toes, night pain uncomfortable after a variety of treatments invalid in July the same year for the left lower extremity amputation. Pathological diagnosis as follows: 1. left lower extremity marble bone; 2. left femoral atherosclerosis, calcification and ossification of the middle; 3. left toe and 1/3 dorsum of chronic jaundice. In early 1974, the right toe was black and accompanied by severe pain, but also because of ineffective treatment in the same year in March for the right lower extremity amputation. [Example 2] Male, 22 years old, 1 cases of brother, nearly six years because of both lower extremities