重组嵌合毒素是现代抗肿瘤药物研究的一个令人瞩目的领域.由于化疗药物对人体危害较大和不敏感性等,使毒素在肿瘤治疗方面的作用日益受到重视,利用基因融合的方法制备重组嵌合毒素,使新生的蛋白物质既有毒素的细胞毒作用又有特异结合功能,在体内、体外都显示出良好的杀伤靶细胞作用. Recombinant chimeric toxin is an attractive field in the field of modern antitumor drugs.As the chemotherapeutic drugs are more harmful to humans and insensitive to human beings, the role of toxins in tumor therapy is getting more and more attention, and the methods of gene fusion are used to prepare recombinants Chimeric toxin, so that the new protein material both toxin cytotoxic and specific binding function in vivo and in vitro have shown good killing target cells.