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致癌性三十年代前后,报道了德国和瑞士的重铬酸盐生产工人首批肺癌病例。从早期在美国和英国所进行的数次流行病学调查结果来看,铬酸盐和铬颜料生产工人的肺癌病例确有增多,英国为预期的3倍,美国为28倍。平均潜伏期分别为10.6年,14.5年,21年,27年和15年。根据Langrd等(1975)的研究,颜料厂中接触铬酸铅和铬酸锌的工人,支气管癌的发生率为预期的38倍,潜伏期为17～20年。最近Dalager等(1980)报道在飞机保养工厂接触铬酸锌20年以上的
Carcinogenicity Around the 1930s, the first cases of lung cancer in dichromate-producing workers in Germany and Switzerland were reported. In the early epidemiological survey conducted in the United States and Britain, the incidence of lung cancer in chromate and chrome pigment producers did increase, three times that in the United Kingdom and 28 times in the United States. The average incubation period was 10.6 years, 14.5 years, 21 years, 27 years and 15 years. According to a study by Langrd et al. (1975), workers exposed to lead chromate and zinc chromate in a pigment plant had a predicted 38-fold incidence of bronchoconstructions and an incubation period of 17-20 years. Recently Dalager et al. (1980) reported that exposure of zinc chromate to the aircraft maintenance plant for more than 20 years