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核因子-κB(NF-κB)是一类近年颇受关注的细胞核转录调节因子,通过调节众多基因的转录参与多种生理、病理过程的调节。目前已至少阐明三条NF-κB信号途径,其核心均为NF-κB二聚体从抑制性分子中的释放,而且二聚体特异位点磷酸化后,才具转录调节活性。NF-κB通过调节免疫调节因子在机体免疫中起重要作用,并通过调节炎症相关因子参与炎症反应;NF-κB可促进细胞的增生,降低凋亡,促进血管新生和肿瘤细胞的转移能力,在肿瘤的发生、发展中起重要作用,并成为连接慢性炎症和肿瘤发生的重要分子。
Nuclear factor-κB (NF-κB) is a type of nuclear transcriptional regulator that has attracted much attention in recent years. It regulates many physiological and pathological processes by regulating the transcription of many genes. At least three NF-κB signaling pathways have now been elucidated, the core of which is the release of NF-κB dimers from inhibitory molecules, and the phosphorylation of dimeric specific sites is followed by transcriptional regulation. NF-kappaB plays an important role in immune system by regulating immunomodulatory factors and participates in inflammation through regulating inflammation-related factors. NF-kappaB can promote cell proliferation, reduce apoptosis and promote angiogenesis and tumor cell metastasis. Tumor occurrence and development play an important role, and become connected with chronic inflammation and tumorigenesis of important molecules.