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目的探讨围生期解脲支原体(ureaplasma urealyticum,UU)感染与不良妊娠结局、母婴垂直传播的关系。方法采用PCR检测方法对232例产妇进行分娩前1周的宫颈分泌物检测(UU-DNA),同时对UU阳性母亲所生新生儿进行口腔分泌物UU-DNA检测。结果 PCR-UU检测阳性率32.33%,UU阳性母亲所生新生儿口腔分泌物PCR-UU检测阳性率为52.00%。经阴道分娩的新生儿UU阳性率61.22%高于剖宫产分娩者34.61%(P<0.05)。UU阳性孕妇围生期并发症发生率明显高于阴性者(P<0.05)。将UU检测阻性的患者为阳性组;UU检测阴性的患者为阴性组。结论产妇UU感染常与胎儿早产、胎膜早破、足月低体重、新生儿窒息和新生儿肺炎发生关联,为降低新生儿UU垂直感染率,产前检查应常规检测UU,并对UU阳性的孕妇早期进行治疗,从而避免发生不良妊娠结局。
Objective To investigate the relationship between perinatal ureaplasma urealyticum (UU) infection and unfavorable pregnancy outcomes and the vertical transmission of mother and infant. Methods UU-DNA was detected in 232 pregnant women during the first week before delivery by PCR. UU-DNA was also detected in oral secretions of newborns born to UU-positive mothers. Results The positive rate of PCR-UU detection was 32.33%. The positive rate of PCR-UU in oral secretions of neonates born to UU-positive mothers was 52.00%. The positive rate of UU in vaginal delivery was 61.22% higher than that in cesarean section delivery (34.61%, P <0.05). The incidence of perinatal complications in UU positive pregnant women was significantly higher than that in negative pregnant women (P <0.05). Patients with resistive UU testing were positive; patients with negative UU testing were negative. Conclusions Maternal UU infection is often associated with fetal premature rupture of membranes, premature rupture of membranes, full-term low birth weight, neonatal asphyxia and neonatal pneumonia. In order to reduce the incidence of UU vertical infection, UU should be routinely detected in prenatal examination and positive for UU Of pregnant women early treatment, so as to avoid adverse pregnancy outcomes.