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氨基糖苷类抗生素有时需要通过静脉给药,为了使实验药物托普霉素在静脉注射给药后所得到的血浓度和肌肉注射给药时的血浓度相一致,进行了以下的研究。自愿健康成人四名,年龄平均22.4岁。体重平均63.3kg,按1mg/kg体重剂量给药,托普霉素1mg溶解于48ml的生理食盐水中,用连续注射泵静脉注射。另外用相同剂量的托普霉素肌肉注射给药,隔一定时间采血样。每人进行研究时间为一个月以上,交叉进行。
Aminoglycoside antibiotics may sometimes need to be administered intravenously. In order to make the blood concentration of the experimental drug tobramycin obtained after intravenous administration consistent with the blood concentration of the intramuscular injection, the following studies were conducted. Four voluntary and healthy adults, average 22.4 years old. Body weight average 63.3kg, according to the dose of 1mg / kg body weight, 1mg of tobramycin dissolved in 48ml of normal saline, intravenous injection with a continuous injection pump. In addition with the same dose of tobramycin intramuscular injection, blood samples taken at regular intervals. Each person to study for more than a month, cross.