本文的体内实验表明亚硒酸钠具有选择性的抑制HA肝癌细胞内环磷腺苷二酯酶的活性,但对环化酶无影响。酶动力学的测定,表明正常肝和肝癌宿主肝中PDE的km值相同,而与肝癌者不同,提示PDE同工酶在组成上或细微结构上可能有某些差异而造成了对亚硒酸钠的反应性不同。 In vivo experiments demonstrated that sodium selenite selectively inhibits the activity of cyclic adenosine di-esterase in HA hepatoma cells, but has no effect on cyclase. The determination of enzyme kinetics showed that the km value of PDE was the same in normal liver and hepatic cancer host liver, but different from liver cancer, suggesting that there may be some differences in the composition or fine structure of PDE isoenzyme, resulting in the formation of paraselenic acid. The reactivity of sodium is different.