柴葛退热止咳颗粒剂是第四军医大学西京医院研制的复方中药制剂,具有疏风解表,清热解毒,止咳化痰之功。自1986年用于临床以来,治疗上呼吸道感染,急性气管炎、肺炎等病疗效显著。为了探讨该药的作用机理,本方应用伤寒—副伤寒三联菌苗致家兔发热,观察其降温作用,对鸡胚内流感病毒的抑制作用,对鼠肺炎病毒及肺指数的抑制作用。 材料和方法 实验用药物为柴葛颗粒剂(柴胡、葛根、黄芩、 Chaige fever relieving cough granules is a compound Chinese medicine preparation developed by Xijing Hospital of the Fourth Military Medical University. It has the functions of deflation, detoxification, and relieving cough and phlegm. Since it was used in clinical practice in 1986, it has been effective in the treatment of upper respiratory tract infections, acute tracheitis, pneumonia and other diseases. In order to explore the mechanism of action of this drug, this party used a typhoid-paratyphoid fever triple vaccine to induce fever in rabbits, observe its cooling effect, inhibition of influenza virus in chicken embryos, inhibition of murine pneumovirus and lung index. Materials and Methods The experimental drugs were Chaige granules (Bupleurum, Pueraria, Astragalus,