论文部分内容阅读
目的观察采用不同方法治疗老年性阴道炎的临床疗效。方法选取100例患有老年性阴道炎于2015年6月—2016年12月在濮阳市人民医院就诊的老年患者为研究对象,设为对照组(50例)与观察组(50例)。对照组:甲硝唑阴道泡腾片每天阴道给药一次,一次一片,一个疗程为15天,共治疗30天。观察组:在对照组治疗方案的基础上使用雌三醇软膏每天阴道给药一次,每次0.5 g。共需治疗五周。用药次数按用药时间递减,每次给药剂量不变。观察两组患者临床疗效、治疗前,治疗后以及随访3个月症状体征评分、不良反应以及复发率。结果在愈率和有效率上比较,对照组低于观察组,有明显差异,具有统计学差异(P<0.05)。在疗前症状体征评分上比较,两组相比,差异无统计学意义(P>0.05);两组患者经过治疗后,体征评分均有所下降,在治疗后体征评分比较,观察组优于对照组,(P<0.05);在治疗后3个月体征评分比较,两组评分均有提高,对照组高于观察组,具有统计学差异(P<0.05)。观察组患者的不良反应发生率略低于对照组,但差异无统计学意义(P>0.05)。观察组患者的复发率明显低于对照组,组间比较差异有统计学意义(P<0.05)。结论老年性阴道炎患者采用雌三醇软膏联合甲硝唑阴道泡腾片进行治疗,有显著地临床效果,降低复发率,且安全性高,适于临床应用。
Objective To observe the clinical efficacy of different methods of treatment of senile vaginitis. Methods A total of 100 elderly patients with senile vaginitis who were treated in Puyang People’s Hospital from June 2015 to December 2016 were selected as the control group (50 cases) and the observation group (50 cases). Control group: Metronidazole vaginal effervescent vaginal administration once a day, one at a time, a course of 15 days, a total of 30 days. Observation group: On the basis of the control group, vaginal administration of estriol ointment was given vaginally once a day for 0.5 g each. A total of five weeks of treatment. The number of medication by medication time decreases, the same dosage each dose. The clinical efficacy, symptom and symptom scores, adverse reactions and relapse rate were observed before treatment, after treatment and 3 months after follow-up. The results in the cure rate and the efficiency of the comparison group was lower than the observation group, there was a significant difference with a statistically significant difference (P <0.05). There was no significant difference between the two groups in symptom and symptom score (P> 0.05). After the treatment, the score of the symptom decreased in both groups. After treatment, the score of the symptom score was better in the observation group than in the observation group (P <0.05). Compared with the observation group, the score of the two groups increased at 3 months after treatment, with statistical significance (P <0.05). The incidence of adverse reactions in observation group was slightly lower than that in control group, but the difference was not statistically significant (P> 0.05). The recurrence rate of observation group was significantly lower than that of control group, the difference was statistically significant (P <0.05). Conclusions The treatment of senile vaginitis with estriol ointment combined with metronidazole vaginal effervescent tablets has significant clinical effect, reduces the recurrence rate, and is safe and suitable for clinical application.