Al~(3+)/graphene composites for electrochemical detection of DNA cleavage

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Herein, we present the electrochemical co-deposition of Al3+/graphene composites directly from an aqueous mixture containing graphene oxide (GO) and Al3+. The obtained Al3+/graphene composites with good electrochemical activity were regarded as an appropriate immobilization platform for double-stranded DNA (dsDNA). The nontoxic redox probe xanthurenic acid (XA) was successfully applied to recognize single-stranded DNA and dsDNA. We illustrated that the scission of dsDNA caused by GO combining with some metal ions could be detected by monitoring the electrochemical signals of XA. Herein, we present the electrochemical co-deposition of Al3 + / graphene composites directly from an aqueous mixture containing graphene oxide (GO) and Al3 +. The obtained Al3 + / graphene composites with good electrochemical activity were as an appropriate immobilization platform for double-stranded DNA (dsDNA). The nontoxic redox probe was successfully applied to recognize single-stranded DNA and dsDNA. We illustrated that the scission of dsDNA caused by GO combining with some metal ions could be detected by monitoring the electrochemical signals of XA .
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