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目的 :在肝细胞癌动物模型上观察聚丙交酯复合乙交酯 (PLcG)微球经肝动脉化疗栓塞术 (TACE)治疗肝癌的疗效。方法 :在雄性ACI大鼠 ( 15例 )肝包膜下植入MorrisHepatoma 392 4A肝癌小瘤块 ( 1mm3) ,移植术后 13天时行磁共振检查。再经正中腹切开术和经胃十二指肠动脉逆行插管进行以下介入治疗 :治疗组A( 40mgPLcG + 0 .0 5mg丝裂霉素 ,4例 )、对照组B( 0 .0 5mg丝裂霉素 + 0 .0 4mg碘化油 +肝动脉结扎 ,4例 )和对照组C( 1.5ml生理盐水 ,7例 )。插管术后 13天再次行磁共振术观察肝肿瘤体积变化。结果 :在C组 ,肿瘤体积在实验期间增长 2 7.12倍 ,在B组 ,肿瘤体积增长 3.76倍 ,而在A组 ,肿瘤体积仅增长 2 .87倍。A组与C组肿瘤体积增长率在t检验时均有显著性差异 (P <0 .0 5 )。结论 :在动物实验中将PLcG微球运用于TACE可明显抑制肝肿瘤生长。
Objective : To observe the therapeutic effect of poly(lactide-co-glycolide)-poly(lactide-co-glycolide) (PLCG) microspheres in transcatheter arterial chemoembolization (TACE) in the treatment of hepatocellular carcinoma in animal models of hepatocellular carcinoma. METHODS: Male liver cancer small tumor blocks (1mm3) were implanted under the liver capsule of male ACI rats (15 cases). Magnetic resonance imaging was performed 13 days after transplantation. The following interventional treatment was performed by mid-abdominal incision and retrogastric duodenal artery retrograde intubation: treatment group A (40 mg PLcG + 0.05 mg mitomycin, 4), and control group B (0.05 mg Mitomycin + 0.4 mg iodized oil + hepatic arterial ligation, 4 patients) and control group C (1.5 ml saline, 7 patients). After 13 days of intubation, magnetic resonance imaging was performed again to observe the changes in liver tumor volume. RESULTS: In group C, the tumor volume increased by 7.12 times during the experimental period; in group B, the tumor volume increased by 3.76 times, whereas in group A, the tumor volume only increased by 2.87 times. The tumor volume growth rates in group A and group C were significantly different on t-test (P < 0.05). Conclusion : The application of PLcG microspheres to TACE in animal experiments can significantly inhibit the growth of liver tumors.