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目的:探讨补体C1q/肿瘤坏死因子相关蛋白1(CTRP1)与急性ST段抬高型心肌梗死(STEMI)患者病变严重程度的相关性。方法:选取2010-09-2015-09在我院首次明确诊断为STEMI且行急诊经皮冠状动脉介入治疗(PCI)的患者246例,根据CTRP1水平分为高CTRP1组和低CTRP1组。结果:低CTRP1组患者Gensini积分比高CTRP1组患者高,差异具有统计学意义(P<0.05)。CTRP1水平随冠脉病变支数和植入支架的数量的增加而降低,且差异均具有统计学意义(P<0.05)。CTRP1与Gensini积分(r=-0.243,P=0.007)、Hs-CRP(r=-0.313,P=0.012)呈负相关,与LVEF(r=0.172,P=0.035)呈正相关。逐步多元线性回归显示:年龄、TC、LDL-C、Hs-CRP、LVEF、左主干病变和冠脉病变支数为Gensini积分的独立影响因素。结论:CTRP1与急性STEMI患者冠脉病变严重程度密切相关,能够作为急性STEMI患者病情严重程度的预测因子。
Objective: To investigate the relationship between complement C1q / tumor necrosis factor-related protein 1 (CTRP1) and the severity of STEMI in patients with acute ST-segment elevation myocardial infarction. Methods: A total of 246 patients with STEMI who underwent percutaneous coronary intervention (PCI) for the first time in our hospital from September 2010 to September 2015 were selected and divided into high CTRP1 group and low CTRP1 group according to the level of CTRP1. Results: The patients with low CTRP1 had higher Gensini score than those with high CTRP1, the difference was statistically significant (P <0.05). The level of CTRP1 decreased with the number of coronary lesions and the number of stents implanted, and the differences were statistically significant (P <0.05). CTRP1 was negatively correlated with Gensini score (r = -0.243, P = 0.007), Hs-CRP (r = -0.313, P = 0.012) and positive correlation with LVEF (r = 0.172, P = 0.035) Stepwise multivariate linear regression analysis showed that age, TC, LDL-C, Hs-CRP, LVEF, left main trunk lesion and coronary lesion count were the independent influential factors of Gensini score. Conclusions: CTRP1 is closely related to the severity of coronary lesions in patients with acute STEMI and can be used as a predictor of the severity of the disease in patients with acute STEMI.