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目的:研究托氟啶固体脂质纳米粒及壳聚糖修饰的托氟啶固体脂质纳米粒的制备方法。方法:采用薄膜-超声分散法制备托氟啶固体纳米脂质粒(TFu-SLNs)及壳聚糖修饰的TFu-SLNs,并对纳米粒的形态、粒径和表面电位进行测定,通过单因素考察及正交设计优化制备方法同时考察处方稳定性。结果:薄膜-超声分散法制备的TFu-SLNs平均粒径为160.2 nm,Zeta电位为-33.12 mV,壳聚糖修饰TFu-SLNs平均粒径为400.3 nm,Zeta电位为+12.87 mV。经壳聚糖修饰后,随着壳聚糖浓度的增加,电位逐渐增大。优化后的处方重复性、稳定性良好。结论:通过采用正交设计法对TFu固体脂质纳米粒处方进行优化,得到TFu固体脂质纳米粒及壳聚糖修饰的TFu固体脂质纳米粒的优化处方。
OBJECTIVE: To study the preparation of solid-phase lipid nanoparticles coated with solid titanium tetrafluoride and solid chitosan. Methods: TFu-SLNs and chitosan-modified TFu-SLNs were prepared by membrane-ultrasonic dispersion method. The morphology, particle size and surface potential of the nanoparticles were determined by single factor Study and Orthogonal Design to Optimize Preparation Methods and Prescription Stability. Results: The average particle size of TFu-SLNs prepared by the membrane-ultrasonic dispersion method was 160.2 nm and the zeta potential was -33.12 mV. The average particle diameter of chitosan-modified TFu-SLNs was 400.3 nm and the zeta potential was +12.87 mV. After chitosan modification, with the increase of chitosan concentration, the potential increases. Optimized prescription repeatability, good stability. Conclusion: The formulation of TFu solid lipid nanoparticles was optimized by orthogonal design, and the optimized formulation of TFu solid lipid nanoparticles and chitosan modified TFu solid lipid nanoparticles was obtained.