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目的了解徐汇区新生儿早产发生的危险因素,为预防早产的发生提供依据。方法采集徐汇区2006年1月1日-2012年12月31日所有在上海市医院内出生的户籍婴儿信息,根据病例对照研究方法,采用单因素非条件Logistic回归分析和多因素非条件Logistic回归分析方法,分析新生儿早产的危险因素。结果2006-2012年徐汇区共38 585例婴儿,平均早产发生率为5.81%。单因素非条件Logistic回归分析认为出生畸形、胎次、产次、胎数、母亲年龄、父亲年龄为早产可能的危险因素。最后通过多因素Logistic回归进行分析,采用逐步前进法,认为母亲年龄、出生畸形和胎数是对早产发生有影响,其OR值分别为1.041(95%CI:1.029~1.054)、2.362(95%CI:1.621~3.442)、31.325(95%CI:27.200~36.074)。结论母亲年龄的增加、多胎以及出生畸形等会增加新生儿早产的危险性。
Objective To understand the risk factors of neonatal preterm birth in Xuhui District and provide evidence for prevention of preterm birth. Methods Xuhui District was collected from January 1, 2006 to December 31, 2012. All the infants born from hospitals in Shanghai were collected according to the case-control study. Univariate non-conditional Logistic regression analysis and multivariate non-conditional Logistic regression Analytical methods to analyze the risk factors of neonatal preterm birth. Results A total of 38 585 infants in Xuhui District from 2006 to 2012 were found. The average prevalence of preterm birth was 5.81%. Univariate non-conditional Logistic regression analysis showed that birth deformity, parity, parity, number of births, maternal age, and father’s age were risk factors for preterm delivery. Finally, multivariate logistic regression analysis and stepwise advancing method showed that maternal age, birth deformity and number of fetuses had an impact on preterm birth, with OR values of 1.041 (95% CI: 1.029-1.054) and 2.362 (95% CI: 1.621-3.442), 31.325 (95% CI: 27.200-36.074). Conclusion The increase of mothers’ age, multiple births and birth deformities will increase the risk of neonatal premature birth.