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目的:探讨使用孟鲁司特钠治疗小儿咳嗽变异性哮喘的临床效果。方法:选取小儿咳嗽变异性哮喘患者140例,随机分为2组。其中对照组67例,观察组73例,使其有可比性。2组患者均给予止咳和氨茶碱治疗,对照组患者同时给予酮替芬片口服,观察组患者同时给予孟鲁司特钠口服。对2组患者治疗效果、治疗时间和费用以及复发情况进行评价。结果:观察组患者临床控制率和有效率均明显高于对照组;症状缓解和咳嗽消失时间分别为均明显短于对照组;不良反应发生率和复发率均明显低于对照组;平均复发时间明显晚于对照组。上述比较2组差异有统计学意义(P<0.05)。2组患者住院费用差别不大(P>0.05)。结论:对小儿咳嗽变异性哮喘息儿实施孟鲁司特钠治疗具有起效快、效果确切、不良反应少、不易复发等优点,是一种安全而有效的治疗手段,可以作为常规用药进行推广。
Objective: To investigate the clinical efficacy of montelukast sodium in the treatment of children with cough variant asthma. Methods: 140 children with cough variant asthma were randomly divided into 2 groups. 67 cases in the control group and 73 cases in the observation group made it comparable. Both groups were given cough and aminophylline treatment, while patients in the control group were treated with ketotifen tablets orally, while those in the observation group were given montelukast sodium orally. The treatment effect, treatment time and cost as well as the recurrence of the two groups of patients were evaluated. Results: The clinical control rate and effective rate in the observation group were significantly higher than those in the control group. The symptoms and the disappearance of cough were significantly shorter than those in the control group. The incidences of adverse reactions and recurrence were significantly lower than those in the control group. The average recurrence time Obviously later than the control group. The above two groups were statistically significant differences (P <0.05). There was no significant difference in hospitalization costs between the two groups (P> 0.05). Conclusion: The effect of montelukast sodium on infants with cough variant asthma is rapid, effective, with few adverse reactions and relapse. It is a safe and effective treatment and can be used as a regular drug to promote .