论文部分内容阅读
在心肌细胞电生理活动中钠通道具有重要作用,它只限于细胞膜某些特定部位,由外侧3个M门和内侧1个H门组成,它的关闭与开放受这些闸门所控制。抗心律失常药物与钠通道脂蛋白结合,使结构改变,通道闸门变窄而妨碍钠离子通过细胞膜使钠通道处于失活状态;而在心肌细胞复极之后,药物又干扰钠通道从失活状态恢复,常用最大除极化速率作为钠通道恢复数目的指标即最大除极化速率越快,钠通道开放数量越多,反之亦然。世界各国广泛采用Vangham Williams的分类法。它以药物对心肌细胞动作电位的
Sodium channels play an important role in the electrophysiological activity of cardiomyocytes. It is confined to some specific parts of the cell membrane and consists of three M-lateral and one H-lateral medial, which are controlled by these gates. Antiarrhythmic drugs and sodium channel lipoprotein binding, structural changes, narrowing of the access gate and sodium ions through the cell membrane so that the sodium channel inactivation; and after cardiomyocytes repolarization, the drug again disrupts the sodium channel from inactivation Recovery, the commonly used maximum depolarization rate as an indicator of the number of sodium channels restored, ie, the greater the maximum rate of depolarization, the greater the number of sodium channels open and vice versa. Vangham Williams’s classification is widely used in all countries of the world. It takes drugs to cardiomyocyte action potentials