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目的观察自拟五藤冲剂联合甲氨蝶呤治疗类风湿关节炎的临床疗效及安全性。方法将102例类风湿关节炎患者随机分为治疗组52例,观察组50例,观察组口服甲氨蝶呤片,治疗组在观察组基础上加口服自拟五藤冲剂,疗程12周,观察治疗前后患者的症状、体征及实验室相关指标的变化。结果治疗组总有效率96.00%,观察组总有效率81.63%,二者比较有统计学差异(P<0.05);治疗后两组在压痛关节数、压痛指数、肿胀指数、肿胀关节数、DAS28评分、CRP、晨僵时间、握力、HAQ评分方面均有统计学差异(P<0.05或P<0.01),在VAS评分、ESR方面无统计学差异(P>0.05)。结论自拟五藤冲剂联合甲氨蝶呤治疗类风湿关节炎可显著改善患者症状、体征及炎性指标,显著优于单用甲氨蝶呤。
Objective To observe the clinical efficacy and safety of self-made Wutang granules combined with methotrexate in the treatment of rheumatoid arthritis. Methods A total of 102 patients with rheumatoid arthritis were randomly divided into treatment group (n = 52), observation group (n = 50), observation group, oral methotrexate tablets, the treatment group Before and after treatment of patients with symptoms and signs and laboratory-related changes in indicators. Results The total effective rate in the treatment group was 96.00%, the total effective rate in the observation group was 81.63%, there was a significant difference between the two groups (P <0.05). After treatment, the number of tender joints, tenderness index, swelling index, swollen joints, DAS28 Score, CRP, morning stiffness time, grip strength, HAQ score (P <0.05 or P <0.01). There was no significant difference in VAS score and ESR (P> 0.05). Conclusion Self-made wu tang granule combined with methotrexate treatment of rheumatoid arthritis can significantly improve the symptoms, signs and inflammatory indicators, significantly better than methotrexate alone.