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目的 了解 1型血管紧张素Ⅱ受体 (ATⅡR 1)基因A116 6C多态性与缺血性脑卒中的关系。方法 利用PCR和分子杂交技术对北京地区 2 94例缺血性脑卒中患者及 2 80例非缺血性脑卒中对照者进行ATⅡR 1基因A116 6C多态性检测和分析。结果 A116 6C多态性位点在两组人群中的分布均符合Hardy Weinberg遗传平衡定律 ,但该位点基因型频率及等位基因频率在两组中分布无差异。结论 本研究结果表明 ,ATⅡR 1基因A116 6C多态性不是中国人群缺血性脑卒中发病的遗传学危险因素
Objective To investigate the relationship between A116 6C polymorphism of angiotensin Ⅱ type 1 receptor (ATⅡR 1) gene and ischemic stroke. Methods PCR and molecular hybridization were used to detect and analyze the A116 6C polymorphism of ATⅡR 1 gene in 2 94 ischemic stroke patients and 280 non-ischemic stroke controls in Beijing. Results The distribution of A116 6C polymorphism loci was in accordance with Hardy Weinberg’s law of genetic balance in both groups, but there was no difference in genotype frequency and allele frequency between the two groups. Conclusion The results of this study indicate that A116 6C polymorphism of ATⅡR 1 gene is not a genetic risk factor for ischemic stroke in Chinese population