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目的:建立寒凝血瘀型家兔模型。方法:采用冰冷刺激的方法复制寒凝血瘀家兔模型,将20只家兔按体重随机分为(1)空白对照组,(2)模型一组,(3)模型二组,(4)模型三组,(5)模型四组,每组4只,采用体征观察、微循环观测、血液流变学检测、凝血象检测评价寒凝血瘀家兔模型的可靠性。结果:造模后,模型组(共4组)家兔与空白组家兔相比,精神欠佳,饮食及饮水量减少,二便稀少,耳朵和眼睛的微血管屈曲有分叉,血液中的全血还原黏度和全血黏度增加,纤维蛋白原有所升高。结论:上述方法建立的寒凝血瘀家兔模型符合中医证候特点和现代医学病理生理学基础,具有一定的理论和实践意义。
Objective: To establish a rabbit model of cold coagulation and blood stasis. Methods: Rabbit models of cold-blood coagulation and blood stasis were duplicated by ice-cold stimulation. Twenty rabbits were randomly divided into (1) blank control group, (2) model group, (3) model two groups, Three groups, (5) four groups of four, with four in each group. The reliability of the model of cold-blood stasis and blood stasis was evaluated by the observation of signs, microcirculation, hemorheology and coagulation test. Results: Compared with rabbits in the blank group, the model group (4 rats in total) had poor psychology, reduced diet and water intake, scarce two stools, bifurcation of capillaries in the ear and eyes, Reduce the viscosity of whole blood and whole blood viscosity, fibrinogen has increased. Conclusion: The model of cold-blood coagulation and blood stasis established by the above method accords with the characteristics of TCM syndromes and the basis of modern medical pathophysiology, and has certain theoretical and practical significance.