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近10余年,由于新化疗药的合成和根据细胞动力学的研究成果所创立的联合化疗方案,使急性白血病的治疗效果取得了相当大的进展。对如何予测该化疗药或化疗方案是否敏感,以便更好的指导白血病的治疗,有不少学者进行了研究。白血病病人对化疗药的反应因素是复杂的,但最重要的是该药对自血病细胞的杀伤能力。给化疗前预测白血病细胞在体内对药物的敏感性将是非常有益的。Epstein等用造血干细胞
In the past 10 years, due to the synthesis of new chemotherapeutic drugs and the combination of chemotherapy based on the research results of cell kinetics, considerable progress has been made in the treatment effect of acute leukemia. How to predict whether the chemotherapy drug or chemotherapy program is sensitive to better guide the treatment of leukemia, many scholars have studied. Leukemia patients response to chemotherapy drugs is complex, but the most important is the drug’s ability to kill leukemia cells. It would be very beneficial to predict the sensitivity of leukemic cells to drugs in vivo before chemotherapy. Epstein et al. Used hematopoietic stem cells