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目的:探讨剖宫产产妇围手术期不同时间使用抗生素与新生儿高胆红素血症的相关性。方法:将260例剖宫产产妇按抗生素治疗均分为2组:研究组于手术前予头孢唑啉,术后同等剂量,间隔8h/次,共3次;对照组术前未用药,术后给头孢唑啉,每日2次,共3日。观察两组新生儿高胆红素血症发生率及热病率。结果:研究组新生儿高胆红素血症的发生率明显低于对照组,差异有显著性(P<0.05);两组热病率比较,差异无显著性。两组抗生素使用时间、人均药物用量、人均费用比较,具有显著性差异(P<0.05)。结论:剖宫产围手术期合理使用抗生素,可降低新生儿高胆红素血症的发生。
Objective: To investigate the correlation between antibiotics and neonatal hyperbilirubinemia during perioperative period in cesarean section. Methods: 260 cases of cesarean section were divided into two groups according to the antibiotic treatment. The study group was given cefazolin before the operation. The same dose was given 8 hours after the operation for 3 times. In the control group, After giving cefazolin, 2 times a day for a total of 3 days. The incidence of neonatal hyperbilirubinemia and fever rate were observed in both groups. Results: The incidence of neonatal hyperbilirubinemia in the study group was significantly lower than that in the control group (P <0.05). There was no significant difference between the two groups in the incidence of hyperbilirubinemia. There was significant difference between the two groups in antibiotic use time, drug consumption per capita and per capita cost (P <0.05). Conclusion: Caesarean section perioperative rational use of antibiotics, can reduce the incidence of neonatal hyperbilirubinemia.