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精子发生(Spermatogenesis)包括有丝分裂、减数分裂和精子形成3个阶段。精子发生过程中,会不断发生一系列时空特异性的表观遗传调控,其中组蛋白翻译后修饰(Post-translational modifications,PTMs)已成为生殖专家的研究热点。组蛋白包括H1、H2A、H2B、H3、H4 5种,通常可以发生甲基化、磷酸化、乙酰化、泛素化等一种或多种PTMs。组蛋白PTMs是独立存在的,同时不同组蛋白PTMs之间又可以形成不同的组合[1],由于DNA与组蛋白的紧密结合,故组蛋白PTMs在基因转录调控过程中发挥着重要作用,不同位点的组蛋白PTMs对基因表达的作用不同,同一位点上组蛋白PTMs数目不同对基因表达的影响也不同[2],因此组蛋白PTMs扩大了DNA密
Spermatogenesis includes three stages of mitosis, meiosis and spermatogenesis. During the process of spermatogenesis, a series of spatiotemporal-specific epigenetic regulation occur continuously. Post-translational modifications (PTMs) have become the hot topics of reproductive experts. Histones, including H1, H2A, H2B, H3, H4 5 species, usually can occur methylation, phosphorylation, acetylation, ubiquitination one or more PTMs. Histone PTMs are independent, and different histone PTMs can form different combinations [1]. Because of the close combination of DNA and histone proteins, histone PTMs play an important role in gene transcription regulation Site histone PTMs have different effects on gene expression, and different numbers of histone PTMs at the same site have different effects on gene expression [2]. Therefore, histone PTMs expand the DNA sequence