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对28例弱精症男子精液中加入不同浓度的尿激酶后,分别在30、60、90和120分钟观察精子的活率和前向运动能力。并对14例患者体内给予尿激酶10天后,比较用药前后精子活率和有前向运动力精子数目的变化。结果:28例精液标本体外加入尿激酶后,30、60、90和120分钟时精子的活率均有提高;前向运动精子的数目亦有增加。体内给药前,14例精子平均活率为44.64±11.79,用药10天后,精子平均活率为64.71±13.01,二者比较有极显著差异(P<0.01)。尿激酶的这一作用可能与它降低精液的粘稠度有关。
After adding different concentration of urokinase to semen of 28 asthenozoospermic men, the sperm motility and forward motility were observed at 30, 60, 90 and 120 minutes respectively. And 14 patients were given urokinase in vivo for 10 days before and after treatment compared sperm motility and the number of motile sperm changes. RESULTS: After the addition of urokinase to 28 semen samples, the sperm motility increased at 30, 60, 90 and 120 minutes. The number of motile sperm also increased. Before in vivo administration, the average survival rate of 14 sperm was 44.64 ± 11.79. After 10 days, the average sperm motility was 64.71 ± 13.01 (P <0.01) ). This effect of urokinase may be related to its ability to reduce sperm consistency.