论文部分内容阅读
目的：探索性激素受体的表达与鼻咽癌（ Ｎ Ｐ Ｃ）生物学行为的关系。方法：用免疫组化 Ｌ Ｓ Ａ Ｂ法，对 ７１例 Ｎ Ｐ Ｃ组织标本作雌激素受体（ Ｅ Ｒ）和孕激素受体（ Ｐ Ｒ）进行测定，并结合 Ｃ Ｔ扫描结果、临床表现进行分析。结果：７１ 例中， Ｅ Ｒ 的－ 、＋ 、、例数分别为４ 例（５．６％ ）、１９ 例（２６．８％ ）、２７ 例（３８．０％ ）和 ２１ 例（２９．６％ ）； Ｐ Ｒ 的－ ，＋ ，例数分别为４１ 例（５７．８％ ）、２８ 例（３９．４％ ）和２ 例（２．８％ ）。肿瘤对咽旁组织的侵袭率、淋巴结的转移率，与 Ｅ Ｒ 的表达成正相关（均 Ｐ＜ ０．０１），与 Ｐ Ｒ的表达亦成正相关（均 Ｐ＜ ０．０５）。结论： Ｎ Ｐ Ｃ属 Ｅ Ｒ， Ｐ Ｒ 高表达类肿瘤， Ｅ Ｒ， Ｐ Ｒ 的阳性强度与 Ｎ Ｐ Ｃ 的侵袭率、淋巴结的转移率成正相关，作 Ｎ Ｐ Ｃ的 Ｅ Ｒ， Ｐ Ｒ 检测，对评估 Ｎ Ｐ Ｃ的生物学行为和预后，有一定意义，并提示可采用内分泌治疗。
Objective: To explore the relationship between sex hormone receptor expression and biological behavior of nasopharyngeal carcinoma (NPC). Methods: Immunohistochemical LASB method was used to determine the expression of ER and progesterone receptor (P R) in 71 cases of N P C tissue specimens. Combined with C T scan results, clinical manifestations Analyze. Results: Among 71 cases, the number of -, +, and E of E R were 4 cases (5.6%), 19 cases (26.8%), 27 cases (38.0%) and 21 cases 29.6%). The number of -, +, and of P R were 41 (57.8%), 28 (39.4%) and 2 (2.8%) respectively. The tumor invasion rate to the parapharyngeal tissues and the lymph node metastasis rate were positively correlated with the expression of E R (all P <0.01), and positively correlated with the expression of P R (all P <0.05). CONCLUSION: N P C is an E R, P R highly expressed tumor. The positive correlation between E R and P R is positively correlated with the invasion rate of N P C and lymph node metastasis. , To assess the biological behavior and prognosis of N P C, has some significance, and prompts the use of endocrine therapy.